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Disease Profile
Buschke-Lowenstein tumor
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Giant condyloma acuminatum involving the prepuce and glans penis; Giant condyloma of Buschke and Löwenstein; GCBL
Categories
Rare Cancers
Summary
Buschke-Lowenstein
Symptoms
Symptoms may include:[2][3][4]
- Cauliflower-shaped mass around the external genitals
- Pain in the area of the mass
- Abscess or fistulas around the mass
- Psychological distress
Buschke-Lowenstein tumors are usually slow growing, but they can invade surrounding
Treatment
Specialists involved in the treatment of someone with a Buschke-Lowenstein tumor may include:
Oncologist - Surgeon
Plastic surgeon - Psychologist
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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HPV Alliance
PO Box 230575
New York, NY 10023
E-mail: https://hpvalliance.org/pages/contact-us
Website: https://hpvalliance.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Buschke-Lowenstein tumor. Click on the link to view a sample search on this topic.
References
- Ben Kridis W, Werda I, Charfi S, et al. Buschke Lowenstein anal tumor: an ambiguous entity. Exp Oncol. 2019; 41(2):182-184. https://pubmed.ncbi.nlm.nih.gov/31262155.
- Fanget F, Pasquer A, Djeudji F, Chabanon J, Barth X. Should the Surgical Management of Buschke-Lowenstein Tumors Be Aggressive? About 10 Cases. Dig Surg. 2017; 34(3):247-252. https://pubmed.ncbi.nlm.nih.gov/27941342.
- Spinu D, Radulescu A, Bratu O, et al. Giant condyloma acuminatum Buschke-Lowenstein disease a literature review. Chirurgia (Bucur). 2014; 109(4):445-450. https://pubmed.ncbi.nlm.nih.gov/25149605.
- Jorgaqi E, Jafferany M. Giant condyloma acuminatum (Buschke-Lowenstein tumor): Combined treatment with surgery and chemotherapy. Dermatol Ther. 2020; 33(1):e13193. https://pubmed.ncbi.nlm.nih.gov/31837245.
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